Formamide → 4-Hydroxypyrido (2,3-d)pyrimidine

HRID 1738830Notes

Reaction equation

HRID 1738830 reaction equation
[NH2:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH:11]([NH2:13])=O>>[N:1]1[C:2]2[N:10]=[CH:9][CH:8]=[CH:7][C:3]=2[C:4](=[O:6])[NH:13][CH:11]=1

Participants

3

Reactant 2

HCID 713FormamideHCID 729302-Aminonicotinic acid

Product 1

HCID 1354402774-Hydroxypyrido (2,3-d)pyrimidineYield 70%

Procedure

2-aminonicotinic acid (1.381 g, 10 mM) and formamide (2.70 g, 60 mM) are heated at 165-170° C. for 2 h by means of an oil bath. The reaction mixture is cooled and the resulting solid recrystallized from water to give about 1.030 g of title compound (70% yield). mp 255-8° C.

Workup

  1. temperatureThe reaction mixture is cooled
  2. customthe resulting solid recrystallized from water

Sources & evidence

ORD record
ord-a2678cf1bc04472cbc6cbfdcee137d79
Source dataset
uspto-grants-1999_10
Patent number
US05965563

Reaction notes

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