HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formamide → 4-Hydroxypyrido (2,3-d)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | 2-Aminonicotinic acid | HCID 72930 | — |
| Product | 4-Hydroxypyrido (2,3-d)pyrimidine | HCID 135440277 | 70% |
Reaction Steps
2-aminonicotinic acid (1.381 g, 10 mM) and formamide (2.70 g, 60 mM) are heated at 165-170° C. for 2 h by means of an oil bath. The reaction mixture is cooled and the resulting solid recrystallized from water to give about 1.030 g of title compound (70% yield). mp 255-8° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05965563 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-a2678cf1bc04472cbc6cbfdcee137d79 |
| Source note | uspto-grants-1999_10 |