Potassium Carbonate → Adenine

HRID 1738832Notes

Reaction equation

HRID 1738832 reaction equation
Cl.[N:2]1[C:10]([NH2:11])=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[N:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[N:2]1[C:10]([NH2:11])=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[N:4][CH:3]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 76219Adenine hydrochloride

Product 1

HCID 190AdenineYield 90%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of N6 -(1-tetralyl) adenine hydrochloride salt (3.018 g, 10 mM) and potassium carbonate (2.764 g, 20 mM) in methanol (60 ml) is stirred at ambient temperature for 0.5 h. The mixture is filtered and the filtrate evaporated under vacuum. The residue is purified by column chromatography using a 93:7 mixture of dichloromethane/methanol as eluant to give pure title compound in 90% yield.

Workup

  1. filtrationThe mixture is filtered
  2. customthe filtrate evaporated under vacuum
  3. customThe residue is purified by column chromatography
  4. additiona 93:7 mixture of dichloromethane/methanol as eluant

Sources & evidence

ORD record
ord-995ade2b90c04615bceb9f95e5712854
Source dataset
uspto-grants-1999_10
Patent number
US05965563

Reaction notes

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