Hydrochloric Acid → HCID 22721777, compound

HRID 1738885Notes

Reaction equation

HRID 1738885 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([C:21]([CH:23]3[CH2:28][CH2:27][N:26]([C:29]4[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=4)[CH2:25][CH2:24]3)=[O:22])[CH:17](OC)[C:16]1=C=O)(=[O:14])=[O:13])[CH:6]=[CH:5]2.[OH-:39].[Na+].Cl.[CH3:42][OH:43]>>[C:42]([CH:17]1[CH2:16][N:15]([S:12]([C:7]2[CH:6]=[CH:5][C:4]3[C:9](=[CH:10][CH:11]=[C:2]([Cl:1])[CH:3]=3)[CH:8]=2)(=[O:14])=[O:13])[CH2:20][CH2:19][N:18]1[C:21]([CH:23]1[CH2:28][CH2:27][N:26]([C:29]2[CH:30]=[CH:31][N:32]=[CH:33][CH:34]=2)[CH2:25][CH2:24]1)=[O:22])([OH:43])=[O:39]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 86754587HCID 86754587, compound

Product 1

HCID 22721777HCID 22721777, compound

Procedure

A mixture of 4-(6-chloronaphth-2-ylsulphonyl)-2-methoxy-carbonyl-1-[1-(4-pyridyl)piperidin-4-ylcarbonyl]piperazine (0.362 g), 1N aqueous sodium hydroxide solution (1.3 ml) and methanol (5 ml) was stirred and heated to reflux for 30 minutes. The mixture was acidified by the addition of 2N aqueous hydrochloric acid (2 ml) and evaporated. The residue was dried to give 2-carboxy-4-(6-chloronaphth-2-ylsulphonyl)-1-[1-(4-pyridyl)piperidin-4-ylcarbonyl]piperazine (0.41 g);

Workup

  1. temperatureheated
  2. temperatureto reflux for 30 minutes
  3. customevaporated
  4. customThe residue was dried

Sources & evidence

ORD record
ord-0f9d20e720374f1c9eeeb513c8691c73
Source dataset
uspto-grants-1999_10
Patent number
US05965559

Reaction notes

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