反应详情

8.7 g (22.2 mMol) [1-(4-fluorobenzyl)indole-3-yl]acetic acid (4-fluorobenzyl)ester are dissolved in 50 ml ethanol. 110 ml 1N sodium hydroxide solution are added and the mixture heated for 1 hour at reflux. After cooling, the aqueous phase is washed with ether, acidulated with concentrated hydrochloric acid and the precipitate filtered.

1. temperaturethe mixture heated for 1 hour
2. temperatureat reflux
3. temperatureAfter cooling
4. washthe aqueous phase is washed with ether
5. filtrationthe precipitate filtered