HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-[1-(4-fluorobenzyl)-1H-indol-3-yl]acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | [1-(4-Fluorobenzyl)indole-3-yl]acetic acid (4-fluorobenzyl)ester | HCID 21840193 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-[1-(4-fluorobenzyl)-1H-indol-3-yl]acetic acid | HCID 2774436 | — |
Reaction Steps
8.7 g (22.2 mMol) [1-(4-fluorobenzyl)indole-3-yl]acetic acid (4-fluorobenzyl)ester are dissolved in 50 ml ethanol. 110 ml 1N sodium hydroxide solution are added and the mixture heated for 1 hour at reflux. After cooling, the aqueous phase is washed with ether, acidulated with concentrated hydrochloric acid and the precipitate filtered.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05965582 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-af84598adf4b4775b1f704be7c31ec12 |
| Source note | uspto-grants-1999_10 |