HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1738924Generated: November 3, 2026
4-Aminopyridine → 1H-Indole-3-acetamide, 1-[(4-fluorophenyl)methyl]-N-4-pyridinyl-
https://huagongshe.com/reaction/1738924
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Aminopyridine | HCID 1727 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 2-[1-(4-fluorobenzyl)-1H-indol-3-yl]acetic acid | HCID 2774436 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1H-Indole-3-acetamide, 1-[(4-fluorophenyl)methyl]-N-4-pyridinyl- | HCID 9885185 | — |
Reaction Steps
3.5 g (12.3 mMol) [1-(4-fluorobenzyl)indole-3-yl]acetic acid are dissolved in 100 ml anhydrous tetrahydrofuran. To this solution are added 2.54 g (12.3 mMol) dicyclohexylcarbodiimide and 1.16 g (12.3 mMol) 4-aminopyridine. After stirring for 24 hours at 0° C., the formed dicyclohexyl urea is separated off. After mixing in the solvent, the residue is purified by column chromatography on silica gel. Eluting agent:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05965582 |
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| Source dataset | uspto-grants-1999_10 |
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| ORD ID | ord-66f2f6ccaa484399b5c9e7df989c5bae |
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| Source note | uspto-grants-1999_10 |
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