反应详情

The product from Step B (0.275 g, 1.01 mmol) was dissolved in ethyl acetate (5 mL). A solution of sodium periodate in water (0.5 g in 5 mL) and ruthenium tetroxide (13 mg, 0.10 mmol) was added, and the heterogeneous reaction stirred vigorously overnight at room temperature. An additional portion of sodium periodate in water was added (0.5 g in 5 mL) and the reaction stirred overnight. The reaction was quenched with 10% sodium thiosulfate, and filtered through celite. The phases were separated, and the organic phase dried over magnesium sulfate. Filtration and evaporation gave the title compound.

1. customthe heterogeneous reaction
2. stirringthe reaction stirred overnight
3. customThe reaction was quenched with 10% sodium thiosulfate
4. filtrationfiltered through celite
5. customThe phases were separated
6. dry with materialthe organic phase dried over magnesium sulfate
7. filtrationFiltration and evaporation