4-(2-Acetoxyethyl)-1-tert-butoxycarbonylpiperidin-2-one → 4-(2-Acetoxyethyl)piperidin-2-one

HRID 1739004Notes

Reaction equation

HRID 1739004 reaction equation
[C:1]([O:4][CH2:5][CH2:6][CH:7]1[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[C:9](=[O:20])[CH2:8]1)(=[O:3])[CH3:2]>C(Cl)Cl.FC(F)(F)C(O)=O>[C:1]([O:4][CH2:5][CH2:6][CH:7]1[CH2:12][CH2:11][NH:10][C:9](=[O:20])[CH2:8]1)(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 218400254-(2-Acetoxyethyl)-1-tert-butoxycarbonylpiperidin-2-one

Product 1

HCID 218400044-(2-Acetoxyethyl)piperidin-2-one

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

The product from Step C is dissolved in 2:1 methylene chloride and trifluoroacetic acid. The reaction is stirred for 1 h, and evaporated, giving the title compound.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-a43955a06a78432397aa8987bc12fed3
Source dataset
uspto-grants-1999_10
Patent number
US05965578

Reaction notes

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