HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 3'-Bromo-4'-(bromomethyl)biphenyl-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 3'-Bromo-4'-methyl-1,1'-biphenyl-2-carbonitrile | HCID 21840338 | — |
| Catalyst | Benzoyl Peroxide | HCID 7187 | — |
| Solvent | 1,1,1,2-Tetrachloroethane | HCID 12418 | — |
| Product | 3'-Bromo-4'-(bromomethyl)biphenyl-2-carbonitrile | HCID 21840371 | 35.4% |
Reaction Steps
5.6 g (0.035 mol) of bromine, dissolved in 20 ml of tetrachloroethane, are added dropwise at 100-110° with UV irradiation to a solution of 8.9 g (0.033 mol) of 3'-bromo-4'-methyl-1,1'-biphenyl-2-carbonitrile in 900 ml of tetrachloroethane after addition of 0.1 g of benzoyl peroxide. After 30 minutes, the reaction mixture is cooled and evaporated in vacuo. The crystalline residue is recrystallized from ethyl acetate and gives 4.1 g of the title compound of m.p. 152-153°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05965592 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-d1d455ffe546451abfe71e32f0d5cd15 |
| Source note | uspto-grants-1999_10 |