Bromine → 3'-Bromo-4'-(bromomethyl)biphenyl-2-carbonitrile

HRID 1739086ノート

反応式

HRID 1739086 の反応式
[Br:1]Br.[Br:3][C:4]1[CH:5]=[C:6]([C:11]2[C:12]([C:17]#[N:18])=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:7]=[CH:8][C:9]=1[CH3:10]>ClCC(Cl)(Cl)Cl.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[Br:3][C:4]1[CH:5]=[C:6]([C:11]2[C:12]([C:17]#[N:18])=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:7]=[CH:8][C:9]=1[CH2:10][Br:1]

参加物

5

反応物 2

HCID 24408BromineHCID 218403383'-Bromo-4'-methyl-1,1'-biphenyl-2-carbonitrile

生成物 1

HCID 218403713'-Bromo-4'-(bromomethyl)biphenyl-2-carbonitrile収率 35.4%

試薬・触媒・溶媒 2

HCID 7187Benzoyl Peroxide触媒HCID 124181,1,1,2-Tetrachloroethane溶媒2 回

実験手順

5.6 g (0.035 mol) of bromine, dissolved in 20 ml of tetrachloroethane, are added dropwise at 100-110° with UV irradiation to a solution of 8.9 g (0.033 mol) of 3'-bromo-4'-methyl-1,1'-biphenyl-2-carbonitrile in 900 ml of tetrachloroethane after addition of 0.1 g of benzoyl peroxide. After 30 minutes, the reaction mixture is cooled and evaporated in vacuo. The crystalline residue is recrystallized from ethyl acetate and gives 4.1 g of the title compound of m.p. 152-153°.

後処理

  1. temperaturethe reaction mixture is cooled
  2. customevaporated in vacuo
  3. customThe crystalline residue is recrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-d1d455ffe546451abfe71e32f0d5cd15
出典データセット
uspto-grants-1999_10
特許番号
US05965592

反応ノート

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