L-Methionine → 4-Nitro-2-phenylbenzoyl-(S)-leucine methyl ester

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Reaction Steps

This compound was prepared through the coupling of 4-nitro-2-phenylbenzoic acid with (L)-leucine methyl ester hydrochloride as for the preparation of the methionine derivative (see Example 26, section A). 1H NMR (CDCl3) δ 8.24-8.26 (m, 2H), 7.86 (d, 8.7 Hz, 1H), 7.41-7.46 (m, 5H), 5.71 (d, 7.4 Hz, 1H), 4.57 (ddd, 1H), 3.67 (s, 3H), 1.37-1.46 (m, 1H), 1.08-1.25 (m, 2H), 0.78 (dd, 6H).

Provenance & Evidence