Imidazole → 1-(4-Nitrophenyl)-1H-imidazole

HRID 1739396노트

반응식

HRID 1739396 반응식
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.[H-].[Na+].Cl[C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=1>CN(C=O)C>[N:1]1([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 74741-Chloro-4-nitrobenzeneHCID 24758Sodium hydride

생성물 1

HCID 1231551-(4-Nitrophenyl)-1H-imidazole수율 93.7%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

9.5 g of imidazole were dissolved in 100 ml of DMF, and the resultant solution was further added with 6.1 g of 60% NaH while cooling it with ice. The solution was then stirred for 30 min. and further for 1 hour at room temperature. Then, the solution was added with 20.0 g of 4-chloronitrobenzene and then stirred for 2 hours at a temperature of from 80 to 85° C. The solution reacted was poured into ice water, and the crystals precipitated was filtered and then dried to obtain 22.5 g of 4-(imidazole-1-yl)nitrobenzene.

후처리

  1. temperaturewhile cooling it with ice
  2. stirringstirred for 2 hours at a temperature of from 80 to 85° C
  3. customThe solution reacted
  4. customthe crystals precipitated
  5. filtrationwas filtered
  6. customdried

출처 및 근거

ORD 기록
ord-41b8994b0f2244cc897d8b94505c097f
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05965743

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