Hydrogen Bromide → (3-Bromopropyl)benzene

HRID 1739398Notes

Reaction equation

HRID 1739398 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9]O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(=O)(=O)(O)O.[BrH:16]>>[C:1]1([CH2:7][CH2:8][CH2:9][Br:16])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 1118Sulfuric AcidHCID 31234Benzenepropanol

Product 1

HCID 12503(3-Bromopropyl)benzene

Procedure

To 3.2 g of 3-phenyl-1-propanol, were added 1.2 g of concentrated sulfuric acid and 6.08 g of 47% aqueous solution of hydrobromic acid, and the resultant solution was heated for 5 hours at 140-150° C. Then, the solution was poured into ice-water and extracted with ethyl acetate. The organic layer resulted was dried with anhydrous magnesium sulfate, and the solvent used was distillated under reduced pressure, thereby affording 4.3 g of 3-phenyl-1-bromopropane.

Workup

  1. extractionextracted with ethyl acetate
  2. customThe organic layer resulted
  3. dry with materialwas dried with anhydrous magnesium sulfate

Sources & evidence

ORD record
ord-43b6d5f3ee53424ea260c735086ee852
Source dataset
uspto-grants-1999_10
Patent number
US05965743

Reaction notes

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