Thionyl Chloride → HCID 21841069, compound

HRID 1739401Notes

Reaction equation

HRID 1739401 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:18]=[CH:17][C:14]([CH2:15]O)=[CH:13][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:21])=O>C(Cl)(Cl)Cl>[C:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:18]=[CH:17][C:14]([CH2:15][Cl:21])=[CH:13][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 285616024-(3-Phenylpropoxy)benzenemethanol

Product 1

HCID 21841069HCID 21841069, compoundYield 99.1%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

3.0 g of 4-(3-phenylpropyloxy)benzyl alcohol were dissolved in 30 ml of chloroform, and 1.77 g of thionyl chloride were further fed dropwise to the resultant solution. The solution was then stirred for 1 hour at room temperature. After completed the reaction, the solution reacted was poured into ice-water and extracted with chloroform. The organic layer resulted was dried with anhydrous magnesium sulfate, and the solvent used was distillated under reduced pressure, thereby affording 3.2 g of 4-(3-phenylpropyloxy)benzylchloride.

Workup

  1. customthe reaction
  2. customthe solution reacted
  3. extractionextracted with chloroform
  4. customThe organic layer resulted
  5. dry with materialwas dried with anhydrous magnesium sulfate

Sources & evidence

ORD record
ord-6f5d723516804e65a8cfc62df20d37b3
Source dataset
uspto-grants-1999_10
Patent number
US05965743

Reaction notes

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