反应详情

3,4-Dimethoxy-6-(2-bromoisonicotinoyl)benzaldehyde dimethyl acetal (13.9 g) and 2 M hydrochloric acid (1 ml) are added to a mixture of acetone (30 ml) and water (5 ml), and the mixture is stirred at room temperature for two hours. The mixture is evaporated to remove the acetone, and the remaining aqueous layer is extracted with chloroform. The extract is washed, dried, and concentrated. The residue is purified by silica gel column chromatography (solvent; chloroform:ethyl acetate=4:1) to give 3,4-dimethoxy-6-(2-bromoisonicotinoyl)benzaldehyde (8.65 g).

1. customThe mixture is evaporated
2. customto remove the acetone
3. extractionthe remaining aqueous layer is extracted with chloroform
4. washThe extract is washed
5. customdried
6. concentrationconcentrated
7. customThe residue is purified by silica gel column chromatography (solvent; chloroform:ethyl acetate=4:1)