反应详情

To a solution of 2-bromo-4-(6,7-dimethoxy-2-methoxycarbonylmethylphthalazin-1(2H)-on-4-yl)pyridine (4.34 g) in tetrahydrofuran (20 ml) is added sodium borohydride (0.76 g), and further thereto is added dropwise with heating a mixture of methanol (3.2 ml) and tetrahydrofuran (5 ml) under reflux over a period of one hour. The reaction mixture is allowed to stand for cooling, and thereto is added water under ice-cooling. The mixture is extracted with chloroform, and the extract is washed, dried and concentrated. The residue is recrystallized from isopropyl ether to give 2-bromo-4-(6,7-dimethoxy-2-hydroxyethylphthalazin-1(2H)-on-4-yl)pyridine (3.08 g).

1. additionfurther thereto is added dropwise
2. temperaturewith heating
3. temperatureunder reflux over a period of one hour
4. temperaturefor cooling
5. temperaturecooling
6. extractionThe mixture is extracted with chloroform
7. washthe extract is washed
8. customdried
9. concentrationconcentrated
10. customThe residue is recrystallized from isopropyl ether