HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 2-Bromo-4-(6,7-dimethoxyphthalazin-1-yl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 3,4-Dimethoxy-6-(2-bromoisonicotinoyl)benzaldehyde | HCID 21840840 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Bromo-4-(6,7-dimethoxyphthalazin-1-yl)pyridine | HCID 21840826 | — |
Reaction Steps
To a solution of 3,4-dimethoxy-6-(2-bromoisonicotinoyl)benzaldehyde (4.5 g) in methanol (70 ml) is added dropwise hydrazine monohydrate (0.8 ml). The reaction mixture is cooled with ice, and the precipitates are collected by filtration, and recrystallized from methanol to give 2-bromo-4-(6,7-dimethoxyphthalazin-1-yl)pyridine (4.01 g) as yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05965730 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-daa5282d355343339542882c9bf68cc2 |
| Source note | uspto-grants-1999_10 |