反应详情

To a solution of 3,4-dimethoxy-6-(2-bromoisonicotinoyl)benzaldehyde (4.5 g) in methanol (70 ml) is added dropwise hydrazine monohydrate (0.8 ml). The reaction mixture is cooled with ice, and the precipitates are collected by filtration, and recrystallized from methanol to give 2-bromo-4-(6,7-dimethoxyphthalazin-1-yl)pyridine (4.01 g) as yellow crystals.

1. temperatureThe reaction mixture is cooled with ice
2. filtrationthe precipitates are collected by filtration
3. customrecrystallized from methanol