2-Amino-5-ethyl-1,3,4-thiadiazole → HCID 21840882, compound

HRID 1739507Notes

Reaction equation

HRID 1739507 reaction equation
[NH2:1][C:2]1[S:3][C:4]([CH2:7][CH3:8])=[N:5][N:6]=1.[I:9][C:10]1[CH:17]=[CH:16][C:13]([CH2:14][Br:15])=[CH:12][CH:11]=1>C(O)C>[BrH:15].[CH2:7]([C:4]1[S:3][C:2](=[NH:1])[N:6]([CH2:14][C:13]2[CH:16]=[CH:17][C:10]([I:9])=[CH:11][CH:12]=2)[N:5]=1)[CH3:8]

Participants

4

Reactant 2

HCID 264442-Amino-5-ethyl-1,3,4-thiadiazoleHCID 9542584-Iodobenzyl bromide

Product 1

HCID 21840882HCID 21840882, compoundYield 64.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-amino-5-ethyl-1,3,4-thiadiazole (42.6 g) and 4-iodobenzyl bromide (89.1 g) in ethanol (500 ml) was heated under reflux for 20 hours. After the reaction mixture was cooled, the crystals so precipitated were collected by filtration and then dried, whereby 83 g of the title compound was obtained.

Workup

  1. temperatureunder reflux for 20 hours
  2. temperatureAfter the reaction mixture was cooled
  3. customthe crystals so precipitated
  4. filtrationwere collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-65fdddd9ff5145c6ad0a3a98e8cad226
Source dataset
uspto-grants-1999_10
Patent number
US05965738

Reaction notes

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