Hydrochloric Acid → HCID 178437931, compound

HRID 1739516Notes

Reaction equation

HRID 1739516 reaction equation
[CH2:1]([C:3]1[S:7][C:6](=[N:8]C(=O)C(F)(F)F)[N:5]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[C:28]3[N:32](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[N:31]=[N:30][N:29]=3)=[CH:18][CH:17]=2)[N:4]=1)[CH3:2].[ClH:52]>O1CCOCC1.O>[ClH:52].[CH2:1]([C:3]1[S:7][C:6](=[NH:8])[N:5]([CH2:15][C:16]2[CH:17]=[CH:18][C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[C:28]3[NH:29][N:30]=[N:31][N:32]=3)=[CH:20][CH:21]=2)[N:4]=1)[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 15263683HCID 15263683, compound

Product 1

HCID 178437931HCID 178437931, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 5-ethyl-2-trifluoroacetylimino-3-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl-1,3,4-thiadiazoline (700 mg) in 1,4-dioxane (10 ml) was added 12N hydrochloric acid (2ml), and they were stirred at room temperature for 18 hours. The solvent was distilled off from the reaction mixture. The residue so obtained was dispersed in water, collected by filtration and then dried, whereby 250 mg of the title compound was obtained.

Workup

  1. distillationThe solvent was distilled off from the reaction mixture
  2. customThe residue so obtained
  3. filtrationcollected by filtration
  4. customdried

Sources & evidence

ORD record
ord-3db440ea89d04e9ca964ee585b3403f2
Source dataset
uspto-grants-1999_10
Patent number
US05965738

Reaction notes

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