Water → HCID 178437927, compound

HRID 1739518Notes

Reaction equation

HRID 1739518 reaction equation
Cl.[CH2:2]([C:4]1[S:8][C:7](=[NH:9])[N:6]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:23]3[NH:27][N:26]=[N:25][N:24]=3)=[CH:13][CH:12]=2)[N:5]=1)[CH3:3].[C:28]12[C:36](=[O:37])[O:35][C:33](=[O:34])[C:29]=1[CH2:30][CH2:31][CH2:32]2.O>CN(C)C=O>[CH2:2]([C:4]1[S:8][C:7](=[N:9][C:36]([C:28]2[CH2:32][CH2:31][CH2:30][C:29]=2[C:33]([OH:35])=[O:34])=[O:37])[N:6]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:23]3[NH:24][N:25]=[N:26][N:27]=3)=[CH:15][CH:16]=2)[N:5]=1)[CH3:3]

Participants

5

Reactant 3

HCID 962WaterHCID 3248541H,3H,4H,5H,6H-cyclopenta(c)furan-1,3-dioneHCID 178437931HCID 178437931, compound

Product 1

HCID 178437927HCID 178437927, compoundYield 63.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 5-ethyl-2-imino-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1,3,4-thiadiazoline hydrochloride (200 mg) in N,N-dimethylformamide (3 ml) was added 1-cyclopentene-1,2-dicarboxylic anhydride (100 mg), and they were stirred at room temperature for 3 days. To the reaction mixture was added water (20 ml), and powders so precipitated were collected by filtration. The powders were washed successively with water, ethanol and diethyl ether and then dried, whereby 160 mg of the title compound was obtained.

Workup

  1. customso precipitated
  2. filtrationwere collected by filtration
  3. washThe powders were washed successively with water, ethanol and diethyl ether
  4. customdried

Sources & evidence

ORD record
ord-8250128cbd854084a51ab5826ddf93d9
Source dataset
uspto-grants-1999_10
Patent number
US05965738

Reaction notes

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