Water → HCID 178437927, compound

HRID 1739519Notes

Reaction equation

HRID 1739519 reaction equation
[CH2:1]([C:3]1[S:7][C:6](=[NH:8])[N:5]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:22]3[NH:26][N:25]=[N:24][N:23]=3)=[CH:12][CH:11]=2)[N:4]=1)[CH3:2].[C:27]12[C:35](=[O:36])[O:34][C:32](=[O:33])[C:28]=1[CH2:29][CH2:30][CH2:31]2.O>CN(C)C=O>[CH2:1]([C:3]1[S:7][C:6](=[N:8][C:35]([C:27]2[CH2:31][CH2:30][CH2:29][C:28]=2[C:32]([OH:34])=[O:33])=[O:36])[N:5]([CH2:9][C:10]2[CH:11]=[CH:12][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:22]3[NH:23][N:24]=[N:25][N:26]=3)=[CH:14][CH:15]=2)[N:4]=1)[CH3:2]

Participants

5

Reactant 3

HCID 962WaterHCID 3248541H,3H,4H,5H,6H-cyclopenta(c)furan-1,3-dioneHCID 178437930HCID 178437930, compound

Product 1

HCID 178437927HCID 178437927, compoundYield 90.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 5-ethyl-2-imino-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1,3,4-thiadiazoline (3.63 g) in N,N-dimethylformamide (30 ml) was added 1-cyclopentene-1,2-dicarboxylic anhydride (1.44 g), and they were stirred at room temperature for 6 hours. To the reaction mixture was added water (200 ml), and powders so precipitated were collected by filtration. The powders so obtained were washed successively with water and methanol and then dried, whereby 4.53 g of the title compound was obtained.

Workup

  1. customso precipitated
  2. filtrationwere collected by filtration
  3. customThe powders so obtained
  4. washwere washed successively with water and methanol
  5. customdried

Sources & evidence

ORD record
ord-2d226ee233044fdfb2c7840e33b0704c
Source dataset
uspto-grants-1999_10
Patent number
US05965738

Reaction notes

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