HCID 21841496, compound → HCID 21841487, compound

HRID 1739566Notes

Reaction equation

HRID 1739566 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[C:4]([F:11])[C:3]=1[C:12]1[CH:17]=[CH:16][C:15]([O:18]CC2C=CC=CC=2)=[CH:14][CH:13]=1>C(OCC)(=O)C.[Pd]>[F:1][C:2]1[CH:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[C:4]([F:11])[C:3]=1[C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=1

Participants

4

Reactant 1

HCID 21841496HCID 21841496, compound

Product 1

HCID 21841487HCID 21841487, compoundYield 92.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

342 mg of the product of Stage C were stirred overnight at 20° C. under a hydrogen atmosphere in 30 ml of ethyl acetate and with 113 mg of 9.5% palladium on activated charcoal. The reaction mixture was filtered and evaporated under reduced pressure to obtain 232.6 mg of the expected product.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-a237fbd21ffd4323bee0d61068ffd2c9
Source dataset
uspto-grants-1999_10
Patent number
US05965763

Reaction notes

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