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HRID1739630

反应详情

EQUATION

反应方程式

HRID 1739630 的结构方程式

REACTANTS

反应物

5
结构：O=C(CCl)C(Cl)Cl
HCID13530

1,1,3-Trichloropropanone

C3H3Cl3O

结构：Nc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1
HCID196473

N-(4-Aminobenzoyl)-L-glutamic acid

C12H14N2O5

结构：CC(=O)[O-].[Na+]
HCID517045

Sodium Acetate

C2H3NaO2

结构：O=N[O-].[Na+]
HCID23668193

Sodium Nitrite

NNaO2

结构：Nc1nc(N)c(N)c(O)n1
HCID178508811

未命名化合物

PRODUCTS

生成物

1
结构：Nc1nc(=O)c2nc(CNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cnc2[nH]1
HCID6037

Folic acid

C19H19N7O6

PROCEDURE

实验过程

At present, PteGlu of folic acids is industrially produced through chemical synthesis. Briefly, three components of 2,4,5-triamino-6-hydroxypyrimidine, 1,1,3-trichloroacetone and p-aminobenzoylglutamic acid are condensed in the presence of sodium nitrite in a solution of sodium acetate to give a crude product of folic acid, PteGlu, and the product is purified through recrystallization.