化工社化工社 化学情報印刷レポート · 研究参考用
1,1,3-Trichloroacetone → CID 6037
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,1,3-Trichloroacetone | HCID 13530 | — |
| 反応物 | N-(4-Aminobenzoyl)-L-glutamic acid | HCID 196473 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | Sodium Nitrite | HCID 23668193 | — |
| 反応物 | HCID 178508811 | HCID 178508811 | — |
| 生成物 | CID 6037 | HCID 6037 | — |
反応手順
At present, PteGlu of folic acids is industrially produced through chemical synthesis. Briefly, three components of 2,4,5-triamino-6-hydroxypyrimidine, 1,1,3-trichloroacetone and p-aminobenzoylglutamic acid are condensed in the presence of sodium nitrite in a solution of sodium acetate to give a crude product of folic acid, PteGlu, and the product is purified through recrystallization.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05968788 |
| 出典データセット | uspto-grants-1999_10 |
| ORD ID | ord-a3e409f1a2884e0ca66da9fbec0fafc4 |
| 出典メモ | uspto-grants-1999_10 |