Hydrogen Peroxide → HCID 18697495, compound

HRID 1739671Notes

Reaction equation

HRID 1739671 reaction equation
[CH3:1][C:2]1([CH3:11])[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[Se:4][NH:3]1.[OH:12]O>CO>[CH3:1][C:2]1([CH3:11])[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[Se:4](=[O:12])[NH:3]1

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 9990749HCID 9990749, compound

Product 1

HCID 18697495HCID 18697495, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The derivative 3,3-dimethyl-benzisoselenazoline BXT-51056 (212 mg; 1 mmole) was dissolved at room temperature in methanol (5 ml) with stirring. After addition of 5% hydrogen peroxide (600 μl; 1.05 mmole), stirring was continued for 15 min. The solvent was evaporated off under reduced pressure. The residue was taken up in 25 ml of dichloromethane and washed with 3×3 ml of a saturated NaCl solution, dried over Na2SO4 then filtered. After evaporation of the solvent under reduced pressure, the desired product was obtained in the form of yellowish crystals.

Workup

  1. stirringstirring
  2. customThe solvent was evaporated off under reduced pressure
  3. washwashed with 3×3 ml of a saturated NaCl solution
  4. dry with materialdried over Na2SO4
  5. filtrationthen filtered
  6. customAfter evaporation of the solvent under reduced pressure

Sources & evidence

ORD record
ord-fe98646e870b4df5bb05b1c8dad6053d
Source dataset
uspto-grants-1999_10
Patent number
US05968920

Reaction notes

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