Water → 4-Benzylpiperazine-1-sulfonamide

HRID 1739737Notes

Reaction equation

HRID 1739737 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:14](N)([NH2:17])(=[O:16])=[O:15].O>O1CCOCC1>[NH2:17][S:14]([N:11]1[CH2:12][CH2:13][N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:9][CH2:10]1)(=[O:16])=[O:15]

Participants

5

Reactant 3

HCID 962WaterHCID 759941-BenzylpiperazineHCID 82267Sulfamide

Product 1

HCID 112305864-Benzylpiperazine-1-sulfonamideYield 65.5%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 1-benzylpiperazine (5 g, 28.4 mmol) and sulphamide (2.77 g) in 1,4-dioxane (25 ml) was heated under reflux for 24 hours. The solution was cooled and poured into water (100 ml). The solid was filtered off, washed with toluene (100 ml) and dried under reduced pressure to give the title compound (4.75 g).

Workup

  1. temperatureunder reflux for 24 hours
  2. temperatureThe solution was cooled
  3. filtrationThe solid was filtered off
  4. washwashed with toluene (100 ml)
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-ff5b110686c0465cad76b5e4ccf8d56d
Source dataset
uspto-grants-1999_10
Patent number
US05968923

Reaction notes

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