Chlorobenzene → HCID 21837546, compound

HRID 1739796Notes

Reaction equation

HRID 1739796 reaction equation
[NH2:1][C:2]1[C:11]2[O:10][CH2:9][CH2:8][O:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.C([O-])([O-])=[O:13].[K+].[K+].Cl[C:19]1C=C[CH:22]=[CH:21][CH:20]=1>>[O:7]1[C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([N:1]3[CH2:22][CH2:21][CH:20]([OH:13])[CH2:19]3)[C:11]=2[O:10][CH2:9][CH2:8]1

Participants

4

Reactant 3

HCID 7964ChlorobenzeneHCID 11430Potassium CarbonateHCID 117883872,3-Dihydro-1,4-benzodioxin-5-amine

Product 1

HCID 21837546HCID 21837546, compound

Procedure

10 g (66 mmol) of 5-amino-2,3-dihydro[1,4]benzodioxin, 7.65 ml of ω, ω'-dibromo-butan-2-ol and 18.25 g of K2CO3 in 125 ml of chlorobenzene are heated at reflux for 18 hours. After removal of the solvent by evaporation, the residue is taken up in methylene chloride and washed with water. Drying and evaporation yield 17.6 g of an oil which corresponds to the expected product.

Workup

  1. temperatureat reflux for 18 hours
  2. customAfter removal of the solvent
  3. customby evaporation
  4. washwashed with water
  5. customDrying
  6. customevaporation yield 17.6 g of an oil which

Sources & evidence

ORD record
ord-0cd1e986798047219176bc23832846d9
Source dataset
uspto-grants-1999_10
Patent number
US05968954

Reaction notes

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