HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 6-(4-chlorobenzoyl)-1-methyl-4-(3-propoxyphenyl)-2(1H)-quinolinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Iodopropane | HCID 33643 | — |
| Reactant | 6-(4-Chlorobenzoyl)-4-(3-hydroxyphenyl)-1-methyl-2(1h)-quinolinone | HCID 21837494 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-(4-chlorobenzoyl)-1-methyl-4-(3-propoxyphenyl)-2(1H)-quinolinone | HCID 21837479 | 100% |
Reaction Steps
A mixture of interm. (7-h) (9.5 g), propyl iodide (5.9 ml) and K2CO3 (10.1 g) was stirred and refluxed for 4 hours. Water was added and the mixture was extracted with DCM. The organic layer was separated, dried (MgSO4), filtered and the solvent was evaporated, yielding 10.4 g (100%) of 6-(4-chlorobenzoyl)-1-methyl-4-(3-propoxyphenyl)-2(1H)-quinolinone (interm. 7-i).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05968952 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-b7b61f2e0b2d4ffbb65ce44b6f7a52a0 |
| Source note | uspto-grants-1999_10 |