反应详情

A mixture of interm. (7-h) (9.5 g), propyl iodide (5.9 ml) and K2CO3 (10.1 g) was stirred and refluxed for 4 hours. Water was added and the mixture was extracted with DCM. The organic layer was separated, dried (MgSO4), filtered and the solvent was evaporated, yielding 10.4 g (100%) of 6-(4-chlorobenzoyl)-1-methyl-4-(3-propoxyphenyl)-2(1H)-quinolinone (interm. 7-i).

1. additionA mixture of interm
2. temperaturerefluxed for 4 hours
3. extractionthe mixture was extracted with DCM
4. customThe organic layer was separated
5. dry with materialdried (MgSO4)
6. filtrationfiltered
7. customthe solvent was evaporated