Water → 6,7-dihydro-5H-pyrrolo[1,2-a][1,5]benzodiazepine

HRID 1740016Notes

Reaction equation

HRID 1740016 reaction equation
[CH:1]1[C:11]2[N:10]3[CH:12]=[CH:13][CH:14]=[C:9]3[CH2:8][C:7](=O)[NH:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.B#B.CSC.O.[OH-].[Na+]>O1CCCC1>[CH:1]1[C:11]2[N:10]3[CH:12]=[CH:13][CH:14]=[C:9]3[CH2:8][CH2:7][NH:6][C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 123593406,7-dihydro-5H-pyrrolo[1,2-a][1,5]benzodiazepin-6-oneHCID 22038413Diborane dimethylsulfide

Product 1

HCID 123593416,7-dihydro-5H-pyrrolo[1,2-a][1,5]benzodiazepineYield 99.9%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a solution of 0.070 g of 6,7-dihydro-5H-pyrrolo[1,2-a][1,5]benzodiazepin-6-one in 2 ml of tetrahydrofuran is added 0.45 ml of a 2.0 M solution of diborane-dimethylsulfide in tetrahydrofuran. The mixture is refluxed for 3 hours, poured into water and make basic with 2 N NaOH. The tetrahydrofuran is removed under vacuum and the residual aqueous mixture extracted with diethyl ether. The extract is washed with brine, dried (Na2SO4) and the solvent removed to give 0.065 g of a colorless oil; one spot by thin layer chromatography (silica gel) with ethyl acetate-hexane (1:2) as solvent (Rf 0.81).

Workup

  1. temperatureThe mixture is refluxed for 3 hours
  2. customThe tetrahydrofuran is removed under vacuum
  3. extractionthe residual aqueous mixture extracted with diethyl ether
  4. washThe extract is washed with brine
  5. dry with materialdried (Na2SO4)
  6. customthe solvent removed

Sources & evidence

ORD record
ord-b86cd0c627b04a7da30d47c95adeb093
Source dataset
uspto-grants-1999_10
Patent number
US05968930

Reaction notes

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