Hydrochloric Acid → HCID 9960804, compound

HRID 1740088Notes

Reaction equation

HRID 1740088 reaction equation
[ClH:1].O.[C:3]([C:6]1[CH:11]=[CH:10][C:9]([N:12]2[C:16](=[O:17])[C:15]([C:18]([N:20]3[CH2:25][CH2:24][CH:23]([O:26][CH2:27][C:28]([OH:30])=[O:29])[CH2:22][CH2:21]3)=[O:19])=[C:14]([C:31]3[CH:36]=[CH:35][C:34]([C:37]4[CH:42]=[CH:41][CH:40]=[CH:39][N:38]=4)=[CH:33][CH:32]=3)[N:13]2[CH3:43])=[CH:8][CH:7]=1)(=[NH:5])[NH2:4]>C(#N)C>[ClH:1].[ClH:1].[C:3]([C:6]1[CH:11]=[CH:10][C:9]([N:12]2[C:16](=[O:17])[C:15]([C:18]([N:20]3[CH2:21][CH2:22][CH:23]([O:26][CH2:27][C:28]([OH:30])=[O:29])[CH2:24][CH2:25]3)=[O:19])=[C:14]([C:31]3[CH:32]=[CH:33][C:34]([C:37]4[CH:42]=[CH:41][CH:40]=[CH:39][N:38]=4)=[CH:35][CH:36]=3)[N:13]2[CH3:43])=[CH:8][CH:7]=1)(=[NH:4])[NH2:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 9960805HCID 9960805, compound

Product 1

HCID 9960804HCID 9960804, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

5 ml of concentrated hydrochloric acid was added to a mixture of 100 ml of water and 5.25 g of 1-(4-amidinophenyl)-4-{[4-(carboxymethyloxy)-1-piperidinyl]carbonyl}-2-methyl-3-[4-(2-pyridyl)phenyl]-2H-pyrazol-5-one to make a solution. The solution was stirred with 1200 ml of acetonitrile for 15 hours, and the precipitated crystals were collected by filtration. The crystals were dried at 60° C. under reduced pressure to give 5.55 g of the title compound as pale yellow crystals.

Workup

  1. filtrationthe precipitated crystals were collected by filtration
  2. customThe crystals were dried at 60° C. under reduced pressure

Sources & evidence

ORD record
ord-38b279fc23a841e38c3121bafab7ce3c
Source dataset
uspto-grants-1999_10
Patent number
US05968967

Reaction notes

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