Water → N-[1-[[2'-[(Methoxycarbonyl)amino][1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-3-t-butoxycarbonylamino-3-methylbutanamide

HRID 1740205Notes

Reaction equation

HRID 1740205 reaction equation
C(OC([C:8]([CH3:27])([CH3:26])[CH:9](N)[C:10]([NH:12][C@@H:13]1[CH2:19][CH2:18][C:17]2[CH:20]=[CH:21][CH:22]=[CH:23][C:16]=2[NH:15][C:14]1=[O:24])=[O:11])=O)(C)(C)C.[H-].[Na+].Br[CH2:31][C:32]1[CH:37]=[CH:36][C:35]([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=2[NH:44][C:45]([O:47][CH3:48])=[O:46])=[CH:34][CH:33]=1.[OH2:49].C[N:51](C)[CH:52]=[O:53]>C(OCC)(=O)C>[CH3:48][O:47][C:45]([NH:44][C:39]1[CH:40]=[CH:41][CH:42]=[CH:43][C:38]=1[C:35]1[CH:36]=[CH:37][C:32]([CH2:31][N:15]2[C:16]3[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=3[CH2:18][CH2:19][C@@H:13]([NH:12][C:10](=[O:11])[CH2:9][C:8]([NH:51][C:52]([O:53][C:8]([CH3:27])([CH3:26])[CH3:9])=[O:49])([CH3:26])[CH3:27])[C:14]2=[O:24])=[CH:33][CH:34]=1)=[O:46]

Participants

7

Reactant 5

HCID 962WaterHCID 6228DimethylformamideHCID 24758Sodium hydrideHCID 218365754-Bromomethyl-2'-(methoxycarbonyl)amino-1,1'-biphenylHCID 675544983-t-butoxycarbonyl-amino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-butanamide

Product 1

HCID 22850224N-[1-[[2'-[(Methoxycarbonyl)amino][1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-3-t-butoxycarbonylamino-3-methylbutanamideYield 63%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of 222 mg (0.594 mmol) of 3-t-butoxycarbonyl-amino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-butanamide (Step I) in 6 mL of dry dimethylformamide was treated with 30 mg of 60% sodium hydride oil dispersion (18 mg NaH, 0.75 mmol, 1.3 eq). The reaction mixture was stirred at room temperature for 30 minutes. To the solution was added 190 mg (0.594 mmol) of solid 4-bromomethyl-2'-(methoxycarbonyl)amino-1,1'-biphenyl. After stirring at room temperature for 1 hour, the reaction mixture was diluted with ethyl acetate followed by 50 mL of water. The organic layer was washed with water (4×), dried over magnesium sulfate, filtered and evaporated under vacuum. The residue was purified by preparative thin layer chromatography on silica gel, eluting with methylene chloride/methanol (100:3) to give 231 mg (0.376 mmol, 63%) of the product. 1H NMR (400 MHz, CDCl3): δ 1.23 (s, 3H), 1.33 (s, 3H), 1.39 (s, 9H), 1.85 (m, 1H), 2.40 (dd, 2H), 2.49 (m, 1H), 2.54 (m, 2H), 3.68 (s, 3H), 4.53 (m, 1H), 4.94 (d, 1H), 5.17 (d, 1H), 6.53 (br s, 1H), 6.66 (d, 1H), 7.2 (m, 12H), 8.09 (d, 1H).

Workup

  1. stirringAfter stirring at room temperature for 1 hour
  2. washThe organic layer was washed with water (4×)
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. customevaporated under vacuum
  6. customThe residue was purified by preparative thin layer chromatography on silica gel
  7. washeluting with methylene chloride/methanol (100:3)

Sources & evidence

ORD record
ord-53cb646561ac4c2486f646715ecfdf7e
Source dataset
uspto-grants-1999_10
Patent number
US05968924

Reaction notes

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