Hydrochloric Acid → HCID 10621295, compound

HRID 1740273Notes

Reaction equation

HRID 1740273 reaction equation
C([O:3][C:4](=[O:27])[C:5]([Cl:26])([Cl:25])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][S:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)C.[OH-].[K+].Cl>C(O)C.C(O)C.O>[Cl:26][C:5]([Cl:25])([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][S:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)[C:4]([OH:27])=[O:3]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium Hydroxide2×HCID 10670423HCID 10670423, compound

Product 1

HCID 10621295HCID 10621295, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 19096565Water ethanolSolvent

Procedure

1.5 g (3.5 mmol) 76 was dissolved in 3.8 ml ethanol and admixed with 3.8 ml 1 N KOH. The precipitate that formed after a short time was dissolved in 20 ml ethanol/water 1:1. 1 ml 1 N KOH was added after 5 h and it was stirred for a further 6 h. After acidifying with 2 N HCl it was extracted with ether, dried over magnesium sulfate and the solvent was removed. 1.18 g (92%) 24 was obtained as colourless crystals of melting point 74° C.

Workup

  1. customThe precipitate that formed after a short time
  2. extractionwas extracted with ether
  3. dry with materialdried over magnesium sulfate
  4. customthe solvent was removed

Sources & evidence

ORD record
ord-738841c029ec40dd9ced78395cd62c82
Source dataset
uspto-grants-1999_10
Patent number
US05968982

Reaction notes

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