Dichloroacetic Acid → HCID 10549874, compound

HRID 1740279Notes

Reaction equation

Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]([CH3:22])([CH3:21])[CH3:20])=[CH:15][CH:14]=1.[Cl:23][CH:24]([Cl:28])[C:25]([OH:27])=[O:26]>>[Cl:23][C:24]([Cl:28])([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]([CH3:22])([CH3:21])[CH3:20])=[CH:15][CH:14]=1)[C:25]([OH:27])=[O:26]

Participants

Reactant 2

HCID 6597Dichloroacetic Acid

HCID 10761595HCID 10761595, compound

Product 1

HCID 10549874HCID 10549874, compoundYield 35%

Procedure

6.8 g (20 mmol) 92 was reacted with 10.3 g (80 mmol) dichloroacetic acid as in example 9. 2.8 g (35%) 41 with a melting point of 56-57° C. was obtained. The sodium salt obtained from 41 and pulverized NaOH in ethanol melted at 178° C. (decomp.).

Sources & evidence

ORD record: ord-cf2711c713c9437cb111e482b04e961f
Source dataset: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05968982

Reaction notes

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