反应详情

Under ice-cooling, 14.0 g of methanesulfonyl chloride was added dropwise to a solution of 23.2 g of 1-(4-chlorophenyl)-3-hydroxymethyl-2-pyrrolidinone and 12.5 g of triethylamine in 200 mL of dichloromethane. After 2 hours, the reaction mixture was washed with water, dried over anhydrous magnesium sulfate and concentrated to give crystals. The crystals were sludged with diethyl ether and collected by filtration. The crystals were washed with diethyl ether and dried in vacuo to give 29.8 g of the title compound.

1. temperatureUnder ice-cooling
2. washthe reaction mixture was washed with water
3. dry with materialdried over anhydrous magnesium sulfate
4. concentrationconcentrated
5. customto give crystals
6. filtrationcollected by filtration
7. washThe crystals were washed with diethyl ether
8. customdried in vacuo