2-Bromoethyl ethyl ether → 1-(2-Ethoxyethyl)piperazine

HRID 1740386Notes

Reaction equation

[CH:1]([N:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)=O.[CH2:9]([O:11][CH2:12]CBr)[CH3:10].COCCN1CCNCC1>>[CH2:9]([O:11][CH2:12][CH2:1][N:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)[CH3:10]

Participants

Reactant 3

HCID 611412-Bromoethyl ethyl ether

HCID 821911-Piperazinecarboxaldehyde

HCID 27346381-(2-Methoxyethyl)piperazine

Product 1

HCID 27346431-(2-Ethoxyethyl)piperazine

Procedure

The title compound was prepared from formylpiperazine and 2-bromoethyl ethyl ether in the same manner as in Preparation Example 1(5) to (7). 1H NMR(CDCl3, δ ppm): 1.19(3H, t), 2.46-2.49(2H, m), 2.55-2.61(4H, m), 2.88-2.92(4H, m), 3.45-3.59(4H, m)

Sources & evidence

ORD record: ord-f654bd77a63742c2a3626de9e6e3ac14
Source dataset: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05969138

Reaction notes

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