HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1740388Generated: October 31, 2026
1,4-Dioxane → 1-(2-(2-Propynyloxy)ethyl)piperazine dihydrochloride
https://huagongshe.com/reaction/1740388
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | Tert-butyl 4-(pent-4-yn-1-yl)piperazine-1-carboxylate | HCID 21838636 | — |
| Product | 1-(2-(2-Propynyloxy)ethyl)piperazine dihydrochloride | HCID 21838637 | — |
Reaction Steps
To a solution of 10.70 g of 1-tert-butoxycarbonyl-4-(2-(2-propynyl)ethyl)piperazine in 1,4-dioxane was added 4N hydrochloric acid/1,4-dioxane, and the mixture was stirred at 60° C. After completion of the reaction, the mixture was concentrated and diethyl ether was added. The solid was collected by filtration and dried to give 11.83 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05969138 |
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| Source dataset | uspto-grants-1999_10 |
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| ORD ID | ord-0004e10095694e5d83afeee1ff6930e5 |
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| Source note | uspto-grants-1999_10 |
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