1-(2-(2-Propynyloxy)ethyl)piperazine → 1-(4-Chlorophenyl)-3-(4-(2-(2-propynyloxy)ethyl)piperazin-1-yl)methyl-2-pyrrolidinone

HRID 1740390Notes

Reaction equation

HRID 1740390 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][CH:10]([CH2:13]OS(C)(=O)=O)[C:9]2=[O:19])=[CH:4][CH:3]=1.[CH2:20]([O:23][CH2:24][CH2:25][N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)[C:21]#[CH:22]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][N:29]3[CH2:30][CH2:31][N:26]([CH2:25][CH2:24][O:23][CH2:20][C:21]#[CH:22])[CH2:27][CH2:28]3)[C:9]2=[O:19])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 218386381-(2-(2-Propynyloxy)ethyl)piperazineHCID 218386401-(4-Chlorophenyl)-3-mesyloxymethyl-2-pyrrolidinone

Product 1

HCID 218386521-(4-Chlorophenyl)-3-(4-(2-(2-propynyloxy)ethyl)piperazin-1-yl)methyl-2-pyrrolidinone

Procedure

The title compound was prepared from 1-(4-chlorophenyl)-3-mesyloxymethyl-2-pyrrolidinone and 1-(2-(2-propynyloxy)ethyl)piperazine, in the same manner as in Preparation Example 1(8).

Sources & evidence

ORD record
ord-5bd40fc376bd4e20b511500991d4fcc3
Source dataset
uspto-grants-1999_10
Patent number
US05969138

Reaction notes

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