L-Tartaric acid → MS-377

HRID 1740397Notes

Reaction equation

HRID 1740397 reaction equation
C(O)(=O)[C@@H]([C@H](C(O)=O)O)O.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([N:18]2[CH2:22][CH2:21][CH:20]([CH2:23][N:24]3[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][O:32][CH3:33])[CH2:26][CH2:25]3)[C:19]2=[O:34])=[CH:14][CH:13]=1>C(O)C>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([N:18]2[CH2:22][CH2:21][C@H:20]([CH2:23][N:24]3[CH2:25][CH2:26][N:27]([CH2:30][CH2:31][O:32][CH3:33])[CH2:28][CH2:29]3)[C:19]2=[O:34])=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 444305L-Tartaric acidHCID 49132091-(4-Chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone

Product 1

HCID 9892249MS-377

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of L-tartaric acid (150 mg) in ethanol (1.5 ml) was added to 1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone (351 mg) in ethanol (6 ml). The solid material thus precipitated was collected and subjected to desalting in an aqueous solution of sodium carbonate to obtain the title compound.

Workup

  1. customThe solid material thus precipitated
  2. customwas collected

Sources & evidence

ORD record
ord-00069616bed54edf95f5b673336c75c6
Source dataset
uspto-grants-1999_10
Patent number
US05969138

Reaction notes

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