反应详情

A solution of 18.7 g of (R)-1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone in 130 mL of methanol was acidified with 4N hydrochloric acid/1,4-dioxane. The precipitated crystals were filtered, washed with diethyl ether and dried in vacuo to give 22.6 g of the title compound.

1. filtrationThe precipitated crystals were filtered
2. washwashed with diethyl ether
3. customdried in vacuo