MS-377 → HCID 9954133, compound

HRID 1740398Notes

Reaction equation

HRID 1740398 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][C@H:10]([CH2:13][N:14]3[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][O:22][CH3:23])[CH2:16][CH2:15]3)[C:9]2=[O:24])=[CH:4][CH:3]=1.[ClH:25].O1CCOCC1>CO>[ClH:1].[ClH:25].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][C@H:10]([CH2:13][N:14]3[CH2:15][CH2:16][N:17]([CH2:20][CH2:21][O:22][CH3:23])[CH2:18][CH2:19]3)[C:9]2=[O:24])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 9892249MS-377HCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 9954133HCID 9954133, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 18.7 g of (R)-1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone in 130 mL of methanol was acidified with 4N hydrochloric acid/1,4-dioxane. The precipitated crystals were filtered, washed with diethyl ether and dried in vacuo to give 22.6 g of the title compound.

Workup

  1. filtrationThe precipitated crystals were filtered
  2. washwashed with diethyl ether
  3. customdried in vacuo

Sources & evidence

ORD record
ord-f4ac9cec17db4db192de0497e3487a15
Source dataset
uspto-grants-1999_10
Patent number
US05969138

Reaction notes

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