HuagongsheHuagongshe Chemistry Print Report · For research reference only
MS-377 free base → HCID 9954133, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | MS-377 free base | HCID 9892249 | — |
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 9954133 | HCID 9954133 | — |
Reaction Steps
A solution of 18.7 g of (R)-1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone in 130 mL of methanol was acidified with 4N hydrochloric acid/1,4-dioxane. The precipitated crystals were filtered, washed with diethyl ether and dried in vacuo to give 22.6 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05969138 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-f4ac9cec17db4db192de0497e3487a15 |
| Source note | uspto-grants-1999_10 |