Sodium Carbonate → HCID 10970201, compound

HRID 1740400Notes

Reaction equation

HRID 1740400 reaction equation
C(O)(=O)[C@H](C1C=CC=CC=1)O.[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]2[CH2:23][CH2:22][C@@H:21]([CH2:24][N:25]3[CH2:30][CH2:29][N:28]([CH2:31][CH2:32][O:33][CH3:34])[CH2:27][CH2:26]3)[C:20]2=[O:35])=[CH:15][CH:14]=1.C(=O)([O-])[O-].[Na+].[Na+]>O>[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]2[CH2:23][CH2:22][C@@H:21]([CH2:24][N:25]3[CH2:26][CH2:27][N:28]([CH2:31][CH2:32][O:33][CH3:34])[CH2:29][CH2:30]3)[C:20]2=[O:35])=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 10340Sodium CarbonateHCID 131721411HCID 131721411, compound

Product 1

HCID 10970201HCID 10970201, compoundYield 95.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Into 2 mL of water was dissolved 180 mg of (S)-1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone (S)-(+)-mandelate, and the solution was desalted with sodium carbonate and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and concentrated to give 120 mg of the title compound.

Workup

  1. extractionextracted with ethyl acetate
  2. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-d36e0e8c5fe644aaadd2d2382afec9d5
Source dataset
uspto-grants-1999_10
Patent number
US05969138

Reaction notes

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