MS-377 → HCID 86754639, compound

HRID 1740404Notes

Reaction equation

HRID 1740404 reaction equation
O.[C:2]1([S:8]([OH:11])(=[O:10])=[O:9])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]2[CH2:23][CH2:22][C@H:21]([CH2:24][N:25]3[CH2:30][CH2:29][N:28]([CH2:31][CH2:32][O:33][CH3:34])[CH2:27][CH2:26]3)[C:20]2=[O:35])=[CH:15][CH:14]=1>C(O)C>[OH2:9].[C:2]1([S:8]([OH:11])(=[O:10])=[O:9])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]2[CH2:23][CH2:22][C@H:21]([CH2:24][N:25]3[CH2:26][CH2:27][N:28]([CH2:31][CH2:32][O:33][CH3:34])[CH2:29][CH2:30]3)[C:20]2=[O:35])=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 9892249MS-377HCID 15619088Hydroxybenzenesulfonic acid

Product 1

HCID 86754639HCID 86754639, compoundYield 154.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of 176 mg of benzenesulfonic acid monohydrate in 10 mL of ethanol was added a solution of 352 mg of (R)-1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone in 10 mL of ethanol. The mixture was concentrated. The residue was sludged with ethanol. The solid formed was filtered and dried to give 407 mg of the title compound.

Workup

  1. concentrationThe mixture was concentrated
  2. customThe solid formed
  3. filtrationwas filtered
  4. customdried

Sources & evidence

ORD record
ord-0ab2c4fd4869408dac0b5a45956d19f5
Source dataset
uspto-grants-1999_10
Patent number
US05969138

Reaction notes

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