HuagongsheHuagongshe Chemistry Print Report · For research reference only
MS-377 free base → HCID 86754640, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | MS-377 free base | HCID 9892249 | — |
| Reactant | Hydroxybenzenesulfonic acid | HCID 15619088 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 86754640 | HCID 86754640 | 87.6% |
Reaction Steps
To a solution of 352 mg of benzenesulfonic acid monohydrate in 10 mL of ethyl acetate was added a solution of 352 mg of (R)-1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone in 10 mL of ethyl acetate. The mixture was stirred at room temperature and cooled. The precipitated solid was filtered and dried to give 585 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05969138 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-8d110df5684a415094d23f7d5d7c361c |
| Source note | uspto-grants-1999_10 |