MS-377 → HCID 86754640, compound

HRID 1740405Notes

Reaction equation

HRID 1740405 reaction equation
O.[C:2]1([S:8]([OH:11])(=[O:10])=[O:9])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]2[CH2:23][CH2:22][C@H:21]([CH2:24][N:25]3[CH2:30][CH2:29][N:28]([CH2:31][CH2:32][O:33][CH3:34])[CH2:27][CH2:26]3)[C:20]2=[O:35])=[CH:15][CH:14]=1>C(OCC)(=O)C>[C:2]1([S:8]([OH:11])(=[O:10])=[O:9])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:2]1([S:8]([OH:11])(=[O:10])=[O:9])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]2[CH2:23][CH2:22][C@H:21]([CH2:24][N:25]3[CH2:26][CH2:27][N:28]([CH2:31][CH2:32][O:33][CH3:34])[CH2:29][CH2:30]3)[C:20]2=[O:35])=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 9892249MS-377HCID 15619088Hydroxybenzenesulfonic acid

Product 1

HCID 86754640HCID 86754640, compoundYield 87.6%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of 352 mg of benzenesulfonic acid monohydrate in 10 mL of ethyl acetate was added a solution of 352 mg of (R)-1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone in 10 mL of ethyl acetate. The mixture was stirred at room temperature and cooled. The precipitated solid was filtered and dried to give 585 mg of the title compound.

Workup

  1. temperaturecooled
  2. filtrationThe precipitated solid was filtered
  3. customdried

Sources & evidence

ORD record
ord-8d110df5684a415094d23f7d5d7c361c
Source dataset
uspto-grants-1999_10
Patent number
US05969138

Reaction notes

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