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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1740406Generated: November 1, 2026

p-Toluenesulfonic acid monohydrate → HCID 86754641, compound

https://huagongshe.com/reaction/1740406

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-Toluenesulfonic acid monohydrateHCID 521998—
ReactantMS-377 free baseHCID 9892249—
SolventEthyl AcetateHCID 8857—
ProductHCID 86754641HCID 86754641194.4%

Reaction Steps

To a solution of 380 mg of p-toluenesulfonic acid monohydrate in 10 mL of ethyl acetate was added a solution of 352 mg of (R)-1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone in 10 mL of ethyl acetate. The mixture was stirred at room temperature and cooled. The precipitated solid was filtered and dried to give 712 mg of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05969138
Source datasetuspto-grants-1999_10
ORD IDord-fda6ce23a59e4ff78afac8cf92d8a5bc
Source noteuspto-grants-1999_10