p-Toluenesulfonic acid monohydrate → HCID 86754641, compound

HRID 1740406Notes

Reaction equation

HRID 1740406 reaction equation
O.[C:2]1([CH3:12])[CH:7]=[CH:6][C:5]([S:8]([OH:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([N:20]2[CH2:24][CH2:23][C@H:22]([CH2:25][N:26]3[CH2:31][CH2:30][N:29]([CH2:32][CH2:33][O:34][CH3:35])[CH2:28][CH2:27]3)[C:21]2=[O:36])=[CH:16][CH:15]=1>C(OCC)(=O)C>[OH2:9].[OH2:34].[C:2]1([CH3:12])[CH:3]=[CH:4][C:5]([S:8]([OH:11])(=[O:9])=[O:10])=[CH:6][CH:7]=1.[C:2]1([CH3:12])[CH:3]=[CH:4][C:5]([S:8]([OH:11])(=[O:9])=[O:10])=[CH:6][CH:7]=1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([N:20]2[CH2:24][CH2:23][C@H:22]([CH2:25][N:26]3[CH2:27][CH2:28][N:29]([CH2:32][CH2:33][O:34][CH3:35])[CH2:30][CH2:31]3)[C:21]2=[O:36])=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 9892249MS-377

Product 1

HCID 86754641HCID 86754641, compoundYield 194.4%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of 380 mg of p-toluenesulfonic acid monohydrate in 10 mL of ethyl acetate was added a solution of 352 mg of (R)-1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone in 10 mL of ethyl acetate. The mixture was stirred at room temperature and cooled. The precipitated solid was filtered and dried to give 712 mg of the title compound.

Workup

  1. temperaturecooled
  2. filtrationThe precipitated solid was filtered
  3. customdried

Sources & evidence

ORD record
ord-fda6ce23a59e4ff78afac8cf92d8a5bc
Source dataset
uspto-grants-1999_10
Patent number
US05969138

Reaction notes

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