HRID1740406

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID521998

4-Methylbenzenesulfonic acid hydrate

C7H10O4S

反应SMILES：COCCN1CCN(C[C@H]2CCN(c3ccc(Cl)cc3)C2=O)CC1

HCID9892249

MS-377

C18H26ClN3O2

PRODUCTS

产物

反应SMILES：COCCN1CCN(C[C@H]2CCN(c3ccc(Cl)cc3)C2=O)CC1.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccc(S(=O)(=O)O)cc1.O.O

HCID86754641

未命名化合物

收率 194.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl Acetate

C4H8O2

2 次

PROCEDURE

实验过程

To a solution of 380 mg of p-toluenesulfonic acid monohydrate in 10 mL of ethyl acetate was added a solution of 352 mg of (R)-1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone in 10 mL of ethyl acetate. The mixture was stirred at room temperature and cooled. The precipitated solid was filtered and dried to give 712 mg of the title compound.

WORKUP

后处理

temperaturecooled
filtrationThe precipitated solid was filtered
customdried

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-fda6ce23a59e4ff78afac8cf92d8a5bc
来源数据集: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US05969138
来源说明: uspto-grants-1999_10

反应SMILES

O.[C:2]1([CH3:12])[CH:7]=[CH:6][C:5]([S:8]([OH:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([N:20]2[CH2:24][CH2:23][C@H:22]([CH2:25][N:26]3[CH2:31][CH2:30][N:29]([CH2:32][CH2:33][O:34][CH3:35])[CH2:28][CH2:27]3)[C:21]2=[O:36])=[CH:16][CH:15]=1>C(OCC)(=O)C>[OH2:9].[OH2:34].[C:2]1([CH3:12])[CH:3]=[CH:4][C:5]([S:8]([OH:11])(=[O:9])=[O:10])=[CH:6][CH:7]=1.[C:2]1([CH3:12])[CH:3]=[CH:4][C:5]([S:8]([OH:11])(=[O:9])=[O:10])=[CH:6][CH:7]=1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([N:20]2[CH2:24][CH2:23][C@H:22]([CH2:25][N:26]3[CH2:27][CH2:28][N:29]([CH2:32][CH2:33][O:34][CH3:35])[CH2:30][CH2:31]3)[C:21]2=[O:36])=[CH:16][CH:15]=1