HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonic Acid → HCID 86754643, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Reactant | MS-377 free base | HCID 9892249 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 86754643 | HCID 86754643 | 82.9% |
Reaction Steps
A solution of 480 mg of methanesulfonic acid in 5 mL of ethyl acetate was added to a solution of 880 mg of (R)-1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone in 15 mL of ethyl acetate. The mixture was stirred at room temperature and cooled. The precipitated solid was filtered and dried to give 1127 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05969138 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-23cad752b9e64390833c7aca00b19962 |
| Source note | uspto-grants-1999_10 |